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KMID : 0931320080080020082
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대한상부위장관.헬리코박터학회지
2008 Volume.8 No. 2 p.82 ~ p.90
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Gastric Mucosal Cytokines, Matrix Metalloproteinase 3, and Pepsinogen Secretion before and after Helicobacter pylori Eradication in Gastroduodenal Phenotypes
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Hwangbo Young
Chang Young-Woon
Oh Hyoung-Chul
Jang Jae-Young
Shim Jae-Jun
Lee Sang-Wook
Ha Sung-Hyung
Lee Young-Ju
Ryu Jeon-Su
Kim Hyo-Jong
Kim Byung-Ho
Chang Rin
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Abstract
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Background/Aims: Relations between host genetic factors and clinical outcomes of Helicobacter pylori (H. pylori) infection are variable among ethnicities. This present study was to examine gastric mucosal cytokines, matrix metalloproteinase (MMP)-3, and serum pepsinogen levels before and after eradication of H. pylori according to Interleukin (IL)-1B genotypes and benign gastroduodenal phenotypes in a Korean population.
Methods: A total of 349 Koreans including H. pylori-infected subjects (n=230) and H. pylori- negative controls (n=119) were enrolled. The former groups were classified into groups according to the presence of non-atrophic gastritis (NAG, n=74), atrophic gastritis (AG, n=56), gastric ulcer (GU, n=37), and duodenal ulcer (DU, n=63). IL-1B polymorphisms were genotyped by PCR-RFLP. Gastric mucosal IL-1?, IL-8 and MMP-3, and serum pepsinogen I and II levels were measured by ELISA and radioimmunoassay, respectively.
Results: There were no significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and CC/TT) frequencies among the H. pylori-positive and negative groups. The genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. pylori-infected atrophic gastritis exhibited significantly higher basal levels of cytokines and a lower pepsinogen I/II ratio than those of other groups. Following H. pylori eradication, inflammatory cytokines significantly decreased and the pepsinogen I/II ratio increased in all groups.
Conclusions: Mucosal inflammatory cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal phenotypes but not IL-1B genotypes. Eradication of H. pylori can reduce mucosal inflammation and restore pepsinogen secretion.
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KEYWORD
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Helicobacter pylori, IL-1B genotypes, Gastroduodenal phenotypes
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